Publications

Large-eddy simulation, convective instability, and modal causality of coaxial supersonic air–water jets considering a swirl effect.

Yanchao, L., Xu, C., Wenkang, W., Weigand, B. (2023).

Physics of Fluids 35, 063316 (2023)

To Publication

Mucosal Adenoviral-vectored Vaccine Boosting Durably Prevents XBB.1.16 Infection in Nonhuman Primates.

Seder, R.A., Gagne, M., Flynn, B.J., Andrew, S.F. et al. (2023).

bioRxiv preprint, November 8, 2023

To Publication

Aerosol delivery of SARS-CoV-2 human monoclonal antibodies in macaques limits viral replication and lung pathology.

Streblow, D.N., Hirsch, A.J., Stanton, J.J. et al. (2023).

Nat Commun 14, 7062 (2023).

To Publication

Transient Aerosol Measurements: Assessing the eFlow Nebulizer Aerosol Bolus.

Heine, B., Hein, C., Njoya, A. & Seemann, S. (2023).
ISAM 2023, International Society for Aerosols in Medicine, Saarbrücken, Germany, August 26-30, 2023.

To Publication

Nebulization of PEGylated recombinant human deoxyribonuclease I using vibrating membrane nebulizers: A technical feasibility study.

Mahri, S., Wilms, T., Hagedorm, P. et al. (2023).
European Journal of Pharmaceutical Sciences, Volume 189, 1 October 2023, 106522.

To Publication

Inhaled pirfenidone solution (AP01) for IPF: a randomised, open-label, dose–response trial.

West, A., Chaudhuri, N., Barczyk, A. et al. (2023).
Thorax, Published Online First: 22 March 2023

To Publication

Differential Performance and Lung Deposition of Levofloxacin with Different Nebulisers Used in Cystic Fibrosis.

Schwarz, C., Procaccianti, C., Costa, L., Brini, R., Friend, R., Caivano, G., Sadafi, H., Mussche, C., Schwenck, N., Hahn, M., Murgia, X. & Bianci, F. (2022).
International Journal of Molecular Sciences 2022, 23(17), 9597

To Publication

A randomized controlled trial of liposomal cyclosporine A for inhalation in the prevention of bronchiolitis obliterans syndrome following lung transplantation.

Neurohr, C., Kneidinger, N., Ghiani, A., Monforte, V., Knoop, C., Jaksch, P., Parmar, J., Ussetti, P., Sole, A., Müller-Quernheim, J., Kessler, R., Wirtz, H., Boerner, G., Denk, O., Prante Fernandes, S. & Behr, J. (2022).
American Journal of Transplantation 2022;22:222–229.

To Publication

Inhaled Medicines: Past, Present, and Future.

Anderson, S., Atkins, P., Bäckman, P., Cipolla, D., Clark, A., Daviskas, E., Disse, B., Entcheva-Dimitrov, P., Fuller, R., Gonda, I., Lundbäck, H., Olsson, B. & Weers, J. (2022).
Pharmacological Reviews January 2022, 74 (1) 48-118.

To Publication

Unsteady Aerosol Output Rate Measurements: Assessing the eFlow Nebulizer Aerosol Bolus.

Heine, B., Keller, J., Dietsche, J., Winzen, A., Schuschnig, U. & Seemann, S. (2022).
Respiratory Drug Delivery (RDD) 2022, Orlando, Florida, May 1-5, 2022 (in person), April 25-June 30, 2022 (virtual), Poster presentation

To Publication

Towards More Realistic In Vitro Nebulizer Testing.

Schuschnig, U., Winzen, A., Heine, B., Schwenck, N. & Seemann, S. (2022).
Respiratory Drug Delivery (RDD) 2022, Orlando, Florida, May 1-5, 2022 (in person), April 25-June 30, 2022 (virtual), Poster presentation.

To Publication

Development of a Novel Test Stand for the Measurement of Valved Holding Chambers with Facemasks.

Winzen, A., Steinfuehrer, K., Schuschnig, U. & Seemann, S. (2022).
Respiratory Drug Delivery (RDD) 2022, Orlando, Florida, May 1-5, 2022 (in person), April 25-June 30, 2022 (virtual), Poster presentation.

To Publication
 

eFlow Technology Nebulisers with Digital Therapy Management: The PARI Connect Eco-System.

Fuchs, C., Buchner, S. (2021).
ONdrugDelivery, Issue 128 (Dec 2021), pp 10–14.

To Publication

Deposition of Inhaled Levofloxacin in Cystic Fibrosis Lungs Assessed by Functional Respiratory Imaging.

Schwarz, C., Procaccianti, C., Mignot, B., Sadafi, H., Schwenck, N., Murgia, X. & Bianco, F. (2021).
Pharmaceutics 2021, 13(12).

To Publication

Impact of baseline clinical features on outcomes of nebulized glycopyrrolate therapy in COPD.

Tashkin, D. P., Niu, X., Sharma, S. & Sanjar, S. (2021).
npj Primary Care Respiratory Medicine, volume 31, Article number: 43 (2021).

To Publication

Self-management intervention to reduce pulmonary exacerbations by supporting treatment adherence in adults with cystic fibrosis: a randomised controlled trial.

Wildman, M. J., O’Cathain, A., Maguire, C., Arden, M. A., Hutchings, M., Bradley, J., Walters, S. J., Whelan, P., Ainsworth, J., Buchan, I., Mandefield, L., Sutton, L., Tappenden, P., Elliott, R. A., Hoo, Z., H., Drabble, S. J., Beever, D. & CFHealthHub Study Team (2021).
Thorax Published Online First: 23 September 2021.

To Publication

The Role of Suboptimal Concentrations of Nebulized Tobramycin in Driving Antimicrobial Resistance in Pseudomonas aeruginosa Isolates in Cystic Fibrosis.

Moore, J. E., Millar, B. C., Ollman-Selinger, M. & Cambridge, L. (2021).
Respiratory Care September 2021, 66 (9) 1446-1457.

To Publication

Robustness of aerosol delivery of amikacin liposome inhalation suspension using the eFlow® Technology.

Li, Z., Perkins, W. & Cipolla, D. (2021).
European Journal of Pharmaceutics and Biopharmaceutics Volume 166, September 2021, Pages 10-18.

To Publication

To synopsis of the publication

Development of an intervention to increase adherence to nebuliser treatment in adults with cystic fibrosis: CFHealthHub.

Arden, M. A., Hutchings, M., Whelan, P., Drabble, S. J., Beever, D., Bradley, J. M., Hind, D., Ainsworth, J., Maguire, C., Cantrill, H., O´Cathain, A. & Wildman, M. (2021).
Pilot and Feasibility Studies volume 7, Article number: 1 (2021).

To Publication

How Cold Is Cold Enough? Refrigeration of the Next-Generation Impactor to Prevent Aerosol Undersizing.

Schuschnig, U., Heine, B. & Knoch, M. (2021)
Journal of Aerosol Medicine and Pulmonary Drug Delivery, Published Online: June 7, 2021.

To Publication

Improvement in Lung Function and Patient-Reported Outcomes in Patients with COPD with Comorbid Anxiety and Depression Receiving Nebulized Glycopyrrolate in the GOLDEN 3 and 4 Studies.

Hanania, N. A., Yohannes, A. M., Ozol-Godfrey, A., Tocco, M., Goodin, Th., Sharma, S. & Sanjar, S. (2021).
International Journal of Chronic Obstructive Pulmonary Disease 2021:16 865–875.

To Publication
 

Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis.

Trapnell, B. C., Inoue, Y., Bonella, F., Morgan, C., Jouneau, S., Bendstrup, E., Campo, I., Papiris, S.A., Yamaguchi, E., Cetinkaya, E., Ilkovich, M. M., Kramer, M. R., Veltkamp, M., Kreuter, M., Baba, T., Ganslandt, C., Tarnow, I., Waterer, G. & Jouhikainen, T. (2020).
New England Journal of Medicine 2020; 383:1635-1644.

To Publication

Improved bioavailability of cromolyn sodium using inhaled PA101 delivered via eFlow^® nebulizer.

Abd-Elaziz, K., Elberink, H. O. & Diamant, Z. (2020).
European Clinical Respiratory Journal 2020, VOL. 7, 1809083.

To Publication
 

Observational Real-World Study to Assess Clinical Characteristics and Device Satisfaction in Patients with COPD Treated with Glycopyrrolate/eFlow^® CS.

Stephenson, J.J., Dembek, C., Caldwell-Tarr, A., Conto, R.M., Paullin, M., Kerwin, E.M. (2020).
Int J Chron Obstruct Pulmon Dis. 2020 Jul 14;15:1713-1727. eCollection 2020.

To Publication

Aerosol Pirfenidone Pharmacokinetics after Inhaled Delivery in Sheep: A Viable Approach to Treating Idiopathic Pulmonary Fibrosis.

Kaminskas, L. M., Landersdorfer, C. B., Bischof, R. J., Leong, N., Ibrahim, J., Davies, A. N., Pham, S., Beck, S., Montgomery, B., Surber, M. W. (2020).
Pharmaceutical Research, volume 37, Article number: 3 (2020).

To Publication

Making Concentrated Antibody Formulations Accessible for Vibrating-Mesh Nebulization.

Beck-Broichsitter, M. (2019).
Journal of Pharmaceutical Sciences 108 (2019) 2588-2592.

To Publication

A Randomized, Double-Blinded, Placebo-Controlled, Dose-Escalation Phase 1 Study of Aerosolized Pirfenidone Delivered via the PARI Investigational eFlow Nebulizer in Volunteers and Patients with Idiopathic Pulmonary Fibrosis.

Khoo, J. K., Montgomery, A. B., Otto, K. L., Surber, M., Faggian, J., Lickliter, J. D., Glaspole, I. (2019).
Journal of aerosol medicine and pulmonary drug delivery, 32(0), 1-6.

To Publication

A randomised single-centre trial of inhaled liposomal cyclosporine for bronchiolitis obliterans syndrome post-lung transplantation.

Iacono, A., Wijesinha, M., Rajagopal, K., Murdock, N., Timofte, I., Griffith, B., Terrin, M. (2019).
ERJ Open Research 2019 5: 00167-2019.

To Publication

Single dose escalation studies with inhaled POL6014, a potent novel selective reversible inhibitor of human neutrophil elastase, in healthy volunteers and subjects with cystic fibrosis.

Barth, P., Bruijnzeel, P., Wach, A., Sellier Kessler, O., Hooftman, L., Zimmermann, J., Naue, N., Huber, B., Heimbeck, I., Kappeler, D., Timmer, W., Chevalier, E. (2019).
Journal of Cystic Fibrosis.

To Publication

Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates.

Vonarburg, C., Loetscher, M., Spycher, M. O., Kropf, A., Illi, M., Salmon, S., Roberts, S., Steinfuehrer, K., Campbell, I., Koernig, S., Bain, J., Edler, M., Baumann, U., Miescher, S., Metzger, D. W., Schaub, A., Käsermann, F. & Zuercher, A. W. (2019).
Respiratory Research 2019.

To Publication
 

In vitro characterization of the eFlow closed system nebulizer with glycopyrrolate inhalation solution.

Pham, S., Ferguson, G. T., Kerwin, E., Goodin, T., Wheeler, A., & Bauer, A. (2018).
Journal of aerosol medicine and pulmonary drug delivery, 31(3), 162-169.

To Publication

Monitoring nebuliser usage & lung function in clinical trials.

Fuchs, C., & Koehler, Y. (2018).
ONdrugDelivery Publishing 2018, June 6th, 87, 66-70.

To Publication

Monitoring adherence to treatment regimen of inhaled medication use in a clinical trial with an investigational eFlow nebulizer (eTrack).

Fuchs, C., Brosig, M., Finke, M., Fiebig, D., Soni, P., Tutuncu, A., Saponjic, R., & Knoch, M. (2017).
European Respiratory Journal 2017, 50.

To Publication

Randomized trial of efficacy and safety of dornase alfa delivered by eRapid nebulizer in cystic fibrosis patients.

Sawicki, G. S., Chou, W., Raimundo, K., Trzaskoma, B., & Konstan, M. W. (2015).
Journal of Cystic Fibrosis, 14(6), 777-783.

To Publication

In-vitro Study of Aerosolised Colistin Delivered to the Nasal Tract via a Pulsating Aerosol Delivery Device (Vibrent^®).

Schuschnig, U., Seidler, A., Seemann, S., & Knoch, M. (2015).
20th International Congress of the International Society for Aerosols in Medicine (ISAM), Munich, Germany, May 30 to June 3, 2015.

To Publication

Drug delivery to paranasal sinuses using pulsating aerosols.

Moeller, W., Schuschnig, U., Bartenstein, P., Meyer, G., Haeussinger, K., Schmid, O., & Becker, S. (2014).
Journal of aerosol medicine and pulmonary drug delivery, 27(4), 255-263.

To Publication

The eFlow ‘‘closed system’’(CS) - a novel device platform for liquid aerosol drug-device combinations.

Gallem, T. (2014).
ONdrugDelivery Publishing 2014, June 19th, 50,13-16 (ondrugdelivery.com).

To Publication

A pharmacokinetics and safety comparison of a highly concentrated tobramycin solution with TOBI.

Griese, M., Eismann, C., Börner, G., Denk, O., Schierholz, J. M., Keller, M., Mazurek, H., & Kappler, M. (2014).
Journal of aerosol medicine and pulmonary drug delivery, 27(3), 185-192.

To Publication

Some cystic fibrosis patients do not tolerate tobramycin dry powder inhalation.

Boerner, G., Prante, S., & Borella, F. (2014).
Journal of Cystic Fibrosis, 13, S121.

To Publication

Topical Drug Delivery in Chronic Rhinosinusitis Patients before and after Sinus Surgery Using Pulsating Aerosols.

Möller, W., Schuschnig, U., Celik, G., Münzing, W., Bartenstein, P., Häussinger, K., Kreyling, W. G., Knoch, M., Canis, M., & Becker, S. (2013).
PloS one, 8(9), e74991.

To Publication

Pulsating Aerosols - New Therapy Options for Upper Airway Diseases.

Möller, W., Schuschnig, U., Becker, S., Saba, G. K., Münzing, W., Bartenstein, P., & Knoch, M. (2013).
Journal of aerosol medicine and pulmonary drug delivery, 26(4), 257-258.

Assessing Modeled CO2 Retention and Rebreathing of a Facemask Designed for Efficient Delivery of Aerosols to Infants.

Mundt, C., Sventitskiy, A., Cehelsky, J. E., Patters, A. B., Tservistas, M., Hahn, M. C., Juhl, G., DeVincenzo, J. P. (2012).
ISRN pediatrics, 2012.

A Comparison of Amount and Speed of Deposition Between the PARI LC STAR^® Jet Nebulizer and an Investigational eFlow^® Nebulizer.

Coates, A. L., Green, M., Leung, K., Chan, J., Ribeiro, N., Ratjen, F., & Charron, M. (2011).
Journal of aerosol medicine and pulmonary drug delivery, 24(3), 157-163.

To Publication

Nasally inhaled pulsating aerosols: lung, sinus and nose deposition.

Moller, W., Saba, G. K., Haussinger, K., Becker, S., Keller, M., & Schuschnig, U. (2011).
Rhinology, 2011.

To Publication

Objective Evaluation of Adherence to Inhaled Liposomal Cyclosporin Therapy for Lung Transplant Patients in a Clinical Trial.

Fuchs, C., Prante, S., Pokorski, R., Lim, H., Denk, O., Seemann, S., & Knoch, M. (2011).
Pediatric Pulmonology, 46(34), 418.

Pulsating aerosols for drug delivery to the sinuses in healthy volunteers.

Möller, W., Schuschnig, U., Khadem Saba, G., Meyer, G., Junge-Hülsing, B., Keller, M., & Häussinger, K. (2010).
Otolaryngology - Head and Neck Surgery, 142(3), 382-388.

To Publication

Lung Deposition of a Liposomal Cyclosporine A Inhalation Solution in Patients after Lung Transplantation.

Behr, J., Zimmermann, G., Baumgartner, R., Leuchte, H., Neurohr, C., Brand, P., Herpich, C., Sommerer, K., Seitz, K., Menges, G., Tillmanns, S., Keller, M., & the Munich Lung Transplant Group (2009).
Journal of aerosol medicine and pulmonary drug delivery, 22(2), 121-130.

To Publication

A Novel Nebuliser for the Simultaneous Administration of siRNA and Supplemental Oxygen for RSV in Infants.

Tservistas, M., Hahn, M., DeVincenzo, J., Hetzer, U., Uhlig, M., Cehelsky, J., Walsh, E., Kreutzer, T., O`Connor, S., Knoch, M. (2009).
Drug Delivery to the Lungs - DDL20, Edinburgh, United Kingdom, December 9-11, 2009. Proceedings: 53-56.

To Publication

New advances in aerosolised drug delivery: vibrating membrane nebuliser technology.

Lass, J. S., Sant, A., & Knoch M. (2006).
Expert opinion on drug delivery, 3(5), 693-702.

To Publication

The customised electronic nebuliser: a new category of liquid aerosol drug delivery systems.

Knoch, M., & Keller M. (2005).
Expert opinion on drug delivery, 2(2), 377-390.

To Publication